Cisco Secure Endpoint
7.4/10
MSP Compared score
- Starting price
- Custom quote
- Reviews
- 4.4/5 (~150 G2 reviews)
- Free trial
- Free trial
- Deployment
- Cloud
- Best for
- Cisco-centric enterprises wanting integrated EDR
Best Endpoint Security & EDR Software · 2026
Cisco Secure Endpoint vs 
ThreatLocker Cisco Secure Endpoint vs ThreatLocker: on our data-weighted scoring, ThreatLocker edges ahead (8.2 vs 7.4/10). Cisco Secure Endpoint starts at Custom quote and is best for cisco-centric enterprises wanting integrated EDR; ThreatLocker starts at Custom quote and is best for MSPs wanting Zero Trust allowlisting and ringfencing. Choose ThreatLocker for the stronger overall track record; consider Cisco Secure Endpoint if its pricing model or fit matches your environment better. Side-by-side table below.
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ThreatLocker
8.2/10
MSP Compared score
- Starting price
- Custom quote
- Reviews
- 4.8/5 (~250 G2 reviews)
- Free trial
- 30 days
- Deployment
- Cloud
- Best for
- MSPs wanting Zero Trust allowlisting and ringfencing
Strengths at a glance
Six criteria, each scored 0–10 on the same scale from real review data, public pricing and feature coverage. See our methodology →
| Criterion | Cisco Secure Endpoint | ThreatLocker |
|---|---|---|
| Editorial | 7.4 | 8.2 |
| User reviews | 8.8 | 9.6 |
| Adoption | 5.8 | 6.4 |
| Affordability | 5.0 | 5.0 |
| Feature breadth | 4.0 | 5.0 |
| Ease of trial | 6.0 | 6.0 |
Cisco Secure Endpoint vs ThreatLocker: head-to-head
| Cisco Secure Endpoint | ThreatLocker | |
|---|---|---|
| Starting price | Custom quote | Custom quote |
| Pricing model | quote | quote |
| Free trial / tier | Free trial | 30 days |
| Best for | Cisco-centric enterprises wanting integrated EDR | MSPs wanting Zero Trust allowlisting and ringfencing |
| Deployment | Cloud | Cloud |
| G2 rating | 4.4/5 (150) | 4.8/5 (250) |
| Capterra rating | — | — |
| Our score | 7.4 | 8.2 |
Choose Cisco Secure Endpoint if…
You need cisco-centric enterprises wanting integrated edr.
✓ Pros
- Talos threat intelligence
- Integrates with Cisco stack
- Solid detection
✕ Cons
- Best within Cisco ecosystem
- Quote pricing
- Heavier admin
Choose ThreatLocker if…
You need msps wanting zero trust allowlisting and ringfencing.
✓ Pros
- Powerful Zero Trust controls
- Excellent support
- Strong MSP fit
✕ Cons
- Allowlisting requires ongoing tuning
- Quote pricing
- Different model than AV/EDR
In depth
Pricing: ThreatLocker vs Cisco Secure Endpoint
ThreatLocker bills on a quote model from Custom quote (30 days trial), while Cisco Secure Endpoint uses a quote model from Custom quote (yes trial). Because the models differ, the cheaper option flips depending on your fleet size — model both at your seat/endpoint count.
Features & deployment
ThreatLocker ships 5 headline capabilities (Application allowlisting, Ringfencing, Storage control, Elevation control) and deploys Cloud. Cisco Secure Endpoint ships 4 (EDR with Talos intel, SecureX/XDR integration, Threat hunting, Sandboxing), deploying Cloud.
Ratings & verdict
ThreatLocker holds 4.8/5 (~250 G2 reviews); Cisco Secure Endpoint holds 4.4/5 (~150 G2 reviews). On our data-weighted score, ThreatLocker edges ahead (8.2 vs 7.4/10). Pick Cisco Secure Endpoint instead when cisco-centric enterprises wanting integrated edr. See ThreatLocker alternatives or Cisco Secure Endpoint alternatives.
Frequently asked questions
- Cisco Secure Endpoint vs ThreatLocker: which is better?
- Cisco Secure Endpoint vs ThreatLocker: on our data-weighted scoring, ThreatLocker edges ahead (8.2 vs 7.4/10). Cisco Secure Endpoint starts at Custom quote and is best for cisco-centric enterprises wanting integrated EDR; ThreatLocker starts at Custom quote and is best for MSPs wanting Zero Trust allowlisting and ringfencing.
- Is Cisco Secure Endpoint cheaper than ThreatLocker?
- Cisco Secure Endpoint starts at Custom quote and ThreatLocker starts at Custom quote (see the pricing rows for models and limits).
Data as of November 1, 2026. Sources: cisco.com, threatlocker.com. Figures are pulled from public vendor and security data and refreshed automatically.