Cisco Secure Endpoint Alternatives (2026)

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Cisco Secure Endpoint
4.4 (150) · G2 7.4/10
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Best for
Cisco-centric enterprises wanting integrated EDR

Our verdict

The top alternatives to Cisco Secure Endpoint are SentinelOne Singularity, CrowdStrike Falcon, ThreatLocker. SentinelOne Singularity is the closest like-for-like option (4.7/5 (~2k G2 reviews), from $69.99/endpoint/yr). People typically switch from Cisco Secure Endpoint over pricing model, complexity, or a missing capability — the table compares each alternative on exactly those axes.

  1. 1SentinelOne Singularity

    ★ Editor's Choice 8.4 4.7 (2000)

    Best for Teams wanting autonomous AI-driven EDR/XDR.

    • Autonomous AI detection
    • Storyline attack visualization
    • EDR/XDR
    • Ranger network discovery
    Free trial Free version
    Visit SentinelOne Singularity → From $69.99/endpoint/yr Cisco Secure Endpoint vs SentinelOne Singularity →

  2. 2CrowdStrike Falcon

    8.3 4.7 (290)

    Best for Organizations wanting best-in-class cloud-native EDR + threat intel.

    • Cloud-native NGAV
    • EDR/XDR
    • Threat intelligence
    • Threat graph
    Free trial Free version
    Visit CrowdStrike Falcon → From $59.99/device/yr Cisco Secure Endpoint vs CrowdStrike Falcon →

  3. 3ThreatLocker

    8.2 4.8 (250)

    Best for MSPs wanting Zero Trust allowlisting and ringfencing.

    • Application allowlisting
    • Ringfencing
    • Storage control
    • Elevation control
    Free trial Free version
    Visit ThreatLocker → From Custom quote Cisco Secure Endpoint vs ThreatLocker →

  4. 4Bitdefender GravityZone

    8.1 4.6 (400)

    Best for SMBs and MSPs wanting strong protection at a fair price.

    • Top-rated AV engine
    • EDR/XDR options
    • Risk analytics
    • Patch + full-disk encryption add-ons
    Free trial Free version
    Visit Bitdefender GravityZone → From Custom quote Cisco Secure Endpoint vs Bitdefender GravityZone →

  5. 5Sophos Intercept X

    8.0 4.6 (350)

    Best for SMBs/MSPs wanting strong EDR plus optional MDR from one vendor.

    • Deep-learning AV
    • EDR/XDR
    • Anti-ransomware (CryptoGuard)
    • Sophos Central management
    Free trial Free version
    Visit Sophos Intercept X → From Custom quote Cisco Secure Endpoint vs Sophos Intercept X →

  6. 6ESET PROTECT

    7.9 4.6 (800)

    Best for Teams wanting lightweight, reliable endpoint protection.

    • Lightweight AV
    • EDR (Inspect)
    • Full-disk encryption
    • Cloud console
    Free trial Free version
    Visit ESET PROTECT → From Custom quote Cisco Secure Endpoint vs ESET PROTECT →

  7. 7Microsoft Defender for Business

    7.8 4.4 (300)

    Best for SMBs already on Microsoft 365 wanting bundled EDR.

    • EDR for SMB
    • Next-gen AV
    • Threat & vulnerability mgmt
    • Auto-investigation
    Free trial Free version
    Visit Microsoft Defender for Business → From $3/user/mo Cisco Secure Endpoint vs Microsoft Defender for Business →

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More alternatives detail

Teams usually move off Cisco Secure Endpoint for one of three reasons: pricing model, complexity, or a missing capability. The closest like-for-like options on the data we track are SentinelOne Singularity, CrowdStrike Falcon, Bitdefender GravityZone.

Frequently asked questions

What is the best alternative to Cisco Secure Endpoint?
SentinelOne Singularity is the top-rated alternative in our data-weighted ranking (from $69.99/endpoint/yr).
Why do people switch from Cisco Secure Endpoint?
Usually pricing model, complexity, or a missing capability. The table compares each alternative on exactly those axes.
Data as of June 1, 2026. Sources: cisco.com. Figures are pulled from public vendor and security data and refreshed automatically.